Neuropeptides 6: 343-350, 1985 B-ENDORPHIN SUPPRESSION OF ACUTE MORPHINE ABSTINENCE IN MORPHINE DEPENDENT MONKEYS: EFFECTIVE GIVEN INTRAVENTRICULARLY BUT INEFFECTIVE GIVEN INTRAVENOUSLY
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چکیده
Six female adult Macaca mulatta monkeys were made dependent upon morphine sulfate and wermanted with a chronic indwelling needle in the lateral ventricle of the brain for sterile intraventricular injections. Both B-endorphin and morphine, in a dose dependent manner given intraventricularly suppressed the signs of 14 hour acute morphine abstinence. On a molar basis, 8-endorphin was more active than morphine in suppressing the signs of morphine abstinence. When given intravenously in much larger doses, B-endorphin was ineffective in contrast to morphine which was effective in suppressing abstinence.
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